Alteration of the cholinergic system and motor deficits in cholinergic neuron-specific Dyt1 knockout mice
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چکیده
منابع مشابه
Motor Deficits and Decreased Striatal Dopamine Receptor 2 Binding Activity in the Striatum-Specific Dyt1 Conditional Knockout Mice
DYT1 early-onset generalized dystonia is a hyperkinetic movement disorder caused by mutations in DYT1 (TOR1A), which codes for torsinA. Recently, significant progress has been made in studying pathophysiology of DYT1 dystonia using targeted mouse models. Dyt1 ΔGAG heterozygous knock-in (KI) and Dyt1 knock-down (KD) mice exhibit motor deficits and alterations of striatal dopamine metabolisms, wh...
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ژورنال
عنوان ژورنال: Neurobiology of Disease
سال: 2021
ISSN: 0969-9961
DOI: 10.1016/j.nbd.2021.105342